The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics (AO). Suchemical unprecedented resolution has highly contributed to understanding retinal function and diseases. However, AO-OCT brings important limitations, such as small field-of-view (FOV) and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. Time domain full-field optical coherence tomography (FFOCT) is a promising imaging modality for high-resolution en-face retinal imaging using a high-speed Megapixel camera, FFOCT was found to behave differently from conventional imaging systems with regard to optical aberrations. Indeed, owing to the use of spatially incoherent illumination, the lateral resolution of FFOCT is less affected by symmetric aberrations, which dominate in the eye. Thus, high- resolution retinal images can be achieved without the use of conventional AO. Although not adversely affecting the resolution, the presence of aberrations still provokes a loss of the signal-to-noise ratio (SNR), Here, we present a clinical-adapted FFOCT and different compact AO strategies based on sensorless approaches to increase the FFOCT SNR and enable to image various retinal features in healthy and diseased patients
About the speaker
lnstitut Langevin, CNRS, Parls, France Paris Eye Imaging Group at the Qμin2e- Vingts National Ophthalmology Hospital in Paris, France
