Computational Genomics Group
Research in our lab focuses on embracing high-throughput single-cell sequencing technologies to understand a cellular heterogeneity of healthy and diseased complex tissues with particular focus on the eye. We encourage highly motivated individuals at all levels of scientific training and background to reach out me regarding opportunities in our lab.
Research Summary
To gain valuable insights into complex biological systems and processes, it is essential to measure features of interest in individual cells. The single-cell transcriptomics and epigenomics allow researchers to uncover rare cell types, reveal the diversity of cell populations, infer the developmental trajectories of cell lineages, and discover their regulatory mechanisms. Recent progress in developing high-throughput single-cell methods allows researchers to study cell types and states of a tremendous number of cells (1 million and beyond).
Contact details:
Phone: +48 609 877 462
Leader: Marcin Tabaka, mtabaka@ichf.edu.pl
Coordinator: Lidia Wolińska-Nizioł, lwolinska-niziol@ichf.edu.pl
Principal Investigator
Group Coordinator and Lab Manager
Post-docs
PhD Students
Research Engineers
Students
Publications
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NAR Genomics and Bioinformatics
Ocelli: an open-source tool for the analysis and visualization of developmental multimodal single-cell data
10.1093/nargab/lqaf0402025
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The Journal of Biological Chemistry
Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration
10.1016/j.jbc.2024.1073442024
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The Journal of Biological Chemistry
Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice
DOI: 10.1016/j.jbc.2024.1072912024
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bioRxiv
Ocelli: a new comprehensive method for multimodal single-cell data analysis
10.1101/2023.10.05.5610742023
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Nature Communications
spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content
10.1038/s41467-023-40322-w2023
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Proceedings of the National Academy of Sciences (PNAS)
Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition
DOI: 10.1073/pnas.22210451202023