
dr Karol Karnowski
Doktor biofizyki, Uniwersytet Mikołaja Kopernika w Toruniu
Lider projektu i starszy badacz
obrazowanie optyczne, optyka obrazowania, biofotonika, przedni odcinek oka ludzkiego, polaryzacja, biomechanika, mikroskopia, sondy światłowodowe
Lider projektu i starszy badacz w dziedzinie biomedycznych zastosowań fotoniki, opracowuje nowe narzędzia i metody służące do: wzmocnienia kontrastu obrazowego, dedykowanych badań przesiewowych lub diagnostycznych różnych patologii, a także ogólnych badań próbek biologicznych.
Obecnie skupia się na wzmocnieniu wolumetrycznego obrazowania optycznego przez różne źródła kontrastu (ruch, polaryzacja, mechanika). Pracuje również nad rozwojem miniaturowych, światłowodowych sond obrazowych dla różnych technik obrazowania.
Publikacje recenzowane:
- R. Lloyd, S. Pirikahu, J. Walter, G. Cadby, E. Darcey, D. Perera, M. Hickey, C. Saunders, K. Karnowski, D. D. Sampson, J. Shepherd, L. Lilge & J. Stone, “Alternative methods to measure breast density in younger women,” British Journal od Cancer, 128, 1701-1709 (2023)
- M. Marcotulli, M. C. Tirelli, M. Volpi, J. Jaroszewicz, C. Scognamiglio, P. Kasprzycki, K. Karnowski, W. Święszkowski, G. Ruocco, M. Costantini, G. Cidonio, A. Barbetta, “Microfluidic 3D Printing of Emulsion Ink for Engineering Porous Functionally Graded Materials,” Advanced Materials Technologies, 8 (5) (2022)
- K. Karnowski, G. Untracht, M. Hackmann, O. Cetinkaya, D Sampson, “Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes,” IEEE Photonics Journal, 14 (5), 1-10 (2022)
- R. Lloyd, J. Walter, S. Pirikahu, G. Cadby, M. Hickey, D.D. Sampson, K. Karnowski, M.J. Hackmann, C. Saunders, L. Lilge, J. Stone, Jennifer, “Assessment of repeated reference measurements to inform the validity of optical breast spectroscopy,” AIP Review of Scientific Instruments, 93, 044101 (2022)
- J. Boguslawski, G. Palczewska, S. Tomczewski, J. Milkiewicz, P. Kasprzycki, D. Stachowiak, K. Komar, M.J. Marzejon, B. Sikorski, A. Hudzikowski, A. Głuszek, A. Łaszczych, K. Karnowski, G. Soboń, K. Palczewski, M. Wojtkowski, „In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope,” The Journal of Clinical Investigation, (2022)
- G. Untrcht, K. Karnowski D. D. Sampson, “Imaging the small with the small: Prospects for photonics in „micro-endomicroscopy for minimally invasive cellular-resolution bioimaging,” APL Photonics, 6 (6), pp. 060901, (2021)
- A. Curatolo, J. S. Birkenfeld, E. Martinez-Enriquez, J. A. Germann, G. Muralidharan, J. Palací, D. Pascual, A. Eliasy, A. Abass, J. Solarski, K. Karnowski, Maciej Wojtkowski, Ahmed Elsheikh, and Susana Marcos, „Multi-meridian corneal imaging of air-puff induced deformation for improved detection of biomechanical abnormalities,” Biomed. Opt. Express 11, 6337-6355 (2020)
- K. Karnowski, Q. Li, A. Poudyal, M. Villiger, C. S. Farah, and D. D. Sampson „Influence of tissue fixation on depth-resolved birefringence of oral cavity tissue samples,” Journal of Biomedical Optics 25(9), 096003 (2020)
- H. Dolezyczek, M. Rapolu, P. Niedzwiedziuk, K. Karnowski, D. Borycki, J. Dzwonek, G. Wilczynski, M. Malinowska, and M. Wojtkowski, „Longitudinal in-vivo OCM imaging of glioblastoma development in the mouse brain,” Biomed. Opt. Express 11, 5003-5016 (2020)
- A. Consejo, J. Solarski, K. Karnowski, J. J. Rozema, M. Wojtkowski, D. R. Iskander, “Keratoconus Detection Based on a Single Scheimpflug Image.” Trans. Vis. Sci. Tech. 2020;9(7):36 (2020)
- P. Gong, Q. Li, Q. Wang, K. Karnowski, D. D. Sampson, „Jones matrix-based speckle-decorrelation angiography using polarization-sensitive optical coherence tomography,” J Biophotonics, 2020;e202000007 (2020)
- Q Li, K Karnowski, G Untracht, PB Noble, B Cense, M Villiger, and DD Sampson, „Vectorial birefringence imaging by optical coherence microscopy for assessing fibrillar microstructures in the cornea and limbus,” Biomed. Opt. Express 11, 1122-1138 (2020)
- A Consejo, K Gławdecka, K Karnowski, J Solarski1, J J Rozema, M Wojtkowski and D. R Iskander, ” Corneal properties of keratoconus based on Scheimpflug light intensity distribution”, Investigative Ophthalmology & Visual Science July Vol.60 (2019)
- J Walther, Q Li, M Villiger, CS Farah, E Koch, K Karnowski, DD Sampson, “Depth-resolved birefringence imaging of collagen fiber organization in the human oral mucosa in vivo”, Biomedical optics express vol. 10, no. 4 (2019)
- E. Maczynska, K. Karnowski, K. Szulzycki, M. Malinowska, H. Dolezyczek, A. Cichanski, M. Wojtkowski, B. Kaluzny and I. Grulkowski, “Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis”, J Biophotonics, 2019; 12:e201800154 (2019). This article among the top 10% most downloaded papers published in Journal of Biophotonics between January 2018 and December 2019
- K. Karnowski, E. Maczynska, M. Nowakowski, B. Kaluzny, I. Grulkowski, M. Wojtkowski, “Impact of diurnal IOP variations on the dynamic corneal hysteresis measured with air-puff swept-source OCT”, Photonics Letters of Poland, (2018)
- Q. Li, K. Karnowski, P.B. Noble, A. Cairncross, A. James, M. Villiger and D. D. Sampson, “Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography”, Biomedical Optics Express, vol. 9, no. 11, pp. 5437-5455 (2018)
- P. Gong, Dao-Yi Yu, Q. Wang, P. Yu, K. Karnowski, M. Heisler, A. Francke, D. An, M. V. Sarunic, and D. D. Sampson, “Label-free volumetric imaging of conjunctival collecting lymphatics ex vivo by optical coherence tomography lymphangiography”, J Biophotonics, vol. 11, no. 8 (2018)
- I. Grulkowski, S. Manzanera, L. Cwiklinski, F. Sobczuk, K. Karnowski, P. Artal, “Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye”, Optica 5, 52-59 (2018)
- Q. Fang, A. Curatolo, P. Wijesinghe, Y. L. Yeow, J. Hamzah, P. Noble, K. Karnowski, D. D. Sampson, R. Ganss, J. K. Kim, W. M. Lee, and B. F. Kennedy, “Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics”, Biomedical Optics Express, vol. 8, no. 11, pp. 5127-5138 (2017) This article was selected for inclusion in January 17, 2018 Spotlight on Optics
- K. Karnowski, A. Ajduk, B. Wieloch, S. Tamborski, K. Krawiec, M. Wojtkowski, M. Szkulmowski, “Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos”, Sci Rep.;7:4165 (2017)
- J.K. Nowak, I. Grulkowski, K. Karnowski, M. Wojtkowski, J. Walkowiak, “Optical Coherence Tomography of the Labial Salivary Glands Reveals Age-Related Differences in Women”, Clin. Trans. Sci *8* (2015); 717-721
- T. Butler, S.Slepneva, B. O’Shauhhnessy, B. Kelleher, D. Goulding, S. p. Hegarty, H. Lyu, K. Karnowski, M. Wojtkowski, “Single shot, time-resolved measurement of the coherence properties of OCT swept source laser”, Opt. Lett. *40* (2015); 2277-2280
- J. K. Nowak, I. Grulkowski, K. Karnowski, M. Wojtkowski, J. Walkowiak, „ Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis”, PLOS ONE *10* (2015); e0117517 – e0117517
- K. Karnowski, I. Grulkowski, N. Mohan, I. Cox, M. Wojtkowski, „ Quantitative optical inspection of contact lenses immersed in wet cell using swept source OCT”, Opt. Lett. *39* (2014); 4727 – 4730 This article was selected for inclusion in Virtual Journal for Biomedical Optics Vol. 9, Iss. 10
- I. Grulkowski, J. Nowak, K. Karnowski, P. Zebryk, M. Puszczewicz, J. Walkowiak, M. Wojtkowski, “Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT”, Biomed. Opt. Express *5* (2014); 259 – 274
- S. Slepneva, B. O’Shaughnessy, B. Kelleher, S. Hegarty, A. Vladimirov, H. Lyu, K., Karnowski, M. Wojtkowski, G. Huyet, “Dynamics of a short cavity swept source OCT laser”, Opt. Express *22* (2014); 18177 – 18185 This article was selected for inclusion in Virtual Journal for Biomedical Optics Vol. 9, Iss. 9
- B. F. Kennedy, M. Wojtkowski, M. Szkulmowski, K. M. Kennedy, K. Karnowski, D. D. Sampson, “Improved measurement of vibration amplitude in dynamic optical coherence elastography”, Biomed. Opt. Express *3* (2012); 3138 – 3152
- K. Karnowski, B. Kaluzny, M. Szkulmowski, M. Gora, and M. Wojtkowski, “Corneal topography with high-speed swept source OCT in clinical examination”, Biomedical Optics Express, Vol. 2, Issue 9 (2011)
- D. Alonso-Caneiro, K. Karnowski, B. Kaluzny, A. Kowalczyk, and M. Wojtkowski, “Assessment of corneal dynamics with high-speed swept source Optical Coherence Tomography combined with an air puff system”, Optics Express, Vol. 19, Issue 15, pp. 14188-14199 (2011)
- B. Kaluzny, M. Gora, K. Karnowski, I. Grulkowski, A. Kowalczyk, and M. Wojtkowski, „Imaging of the Lens Capsule with an Ultrahigh Resolution Spectral Optical Coherence Tomography Prototype Based on a Femtosecond Laser”, Br. J. Ophthalmol, Br J Ophthalmol 2010; 94:275-277
- M. Gora, K. Karnowski, M. Szkulmowski, B. Kaluzny, R. Huber, A. Kowalczyk, M. Wojtkowski, “Ultra-high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range” Optics Express 17(17), 14880- 14894, 2009
Książki:
- S. Marcos, C. Dorronsoro, K. Karnowski, M. Wojtkowski, „Corneal biomechanics From Theory to Practice: OCT with air puff stimulus”, Kugler Publications 2016, edited by C.J. Roberts, J. Liu
Grupy badawcze
Zespół Obrazowania Optycznego
Koncentrujemy się na rozwoju technik obrazowania i wykorzystaniu ich w wielu układach biologicznych i chemicznych. Unikalność naszego podejścia polega na wykorzystaniu nie tylko amplitudy światła, ale również jego fazy w celu opracowania nowych, najwyższej klasy systemów obrazowania.