Nelam Kumar, MS Pharm

He has done a M.S. (Pharm.) in Biotechnology from National Institute of Pharmaceutical Education and Research (NIPER), India. During his master’s thesis, he worked on host pathogen (M.tb) interactions. Later he has joined Dr. R. Ravishankar’s group in CSIR-CDRI, India where he was first introduced to structural biology. The structure biology completely turned his research fascination into passion. Now he is pursuing a PhD in ICTER. He will elucidate the structural complexity of retinal guanylyl cyclases and their modulators for better understanding of eye diseases during his doctoral studies.

A. C. Bisen, S. Agrawal, S. N. Sanap, H. G. Ravi Kumar, N. Kumar, R. Gupta, and R. S. Bhatta. “COVID‐19 retreats and world recovers: A silver lining in the dark cloud.” Health Care Science (2023).
V. Kaushik, L. Gessa, N. Kumar, H. Fernandes. “Towards a New Biomarker for Diabetic Retinopathy: Exploring RBP3 Structure and Retinoids Binding for Functional Imaging of Eyes In Vivo,” International Journal of Molecular Sciences, 24 (5), 4408, (2023).
A. Shukla, M. Afsar, T. Khanam, N. Kumar, F. Ali, S. Kumar, F. Jahan, R. Ramachandran. “Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex.” International Journal of Biological Macromolecules, 225, 442-453, (2023).
A. Shukla, M. Afsar, N. Kumar, S. Kumar, R. Ramachandran. “Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of Mycobacterium tuberculosis NAD⁺-dependent DNA Ligase A, ” Journal of Structural Biology, 213 (1), 107655, (2021).
M. Afsar, A. Shukla, N. Kumar, R. Ramachandran. “Active-site residues and salt-bridges at the subdomain-interfaces of the adenylation domain of Mycobacterium tuberculosis NAD⁺-dependent DNA Ligase A (MtbLigA) are important for initial steps of nick-sealing activity.” Acta Crystallographica Section D, 77 (6), 776-789 (2021).

Research groups

Research aims to elucidate the mechanisms of vision, particularly proteins of the phototransduction pathway and the visual cycle, at an atomic and molecular level.

Projects

17.12.2024

Bridging biology and optics

Two-photon excitation fluorescence (TPEF) is emerging as a powerful imaging technique with superior penetration power in scattering media, allowing for functional imaging of biological tissues at a subcellular level. TPEF is commonly used in cancer diagnostics, as it enables the direct observation of metabolism within living cells. The technique is now widely used in various […]

17.12.2024

Searching new biomarkers of Diabetic retinopathy (DR)

Diabetic retinopathy (DR) is a severe disease with a growing number of afflicted patients, which places a heavy burden on society, both socially and financially. While there are treatments available, they are not always effective and are usually administered when the disease is already at a developed stage with visible clinical manifestation. However, homeostasis at […]

Research groups

Integrated Structural Biology

Projects

Bridging biology and optics

Searching new biomarkers of Diabetic retinopathy (DR)