Natalia Ochocka-Lewicka, PhD

During her doctoral studies Dr. Ochocka-Lewicka studied the role of immune cells in glioma progression at the Nencki Institute of Experimental Biology in Warsaw. She was also engaged in commercial projects on TCR immunotherapies.

Dr. Ochocka-Lewicka was a leader of an NCN Preludium grant. She is also a laureate of the FNP START award and a co-author of 8 publications, including papers in Nature Communications and Cell Reports.

Ochocka N., Segit P., Wojnicki K., Cyranowski S., Swatler J., Jacek K., Grajkowska W., & Kaminska B. (2021). “Specialized functions and sexual dimorphism explain functional diversity of the myeloid populations during glioma progression.” Cell Reports 42 (2023), 111971 https://doi.org/10.1016/j.celrep.2022.111971
Ochocka N., Segit P., Walentynowicz K. A., Wojnicki K., Cyranowski S., Swatler J., Mieczkowski J., & Kaminska B. (2021). ”Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.” Nature Communications, 12(1151), https://doi.org/10.1038/s41467-021-21407-w
Ochocka N, Kaminska B. “Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.” International Journal of Molecular Science. 2021 Mar;22(6). DOI: 10.3390/ijms22063027.
Kaminska B, Ochocka N, Segit P “Single-cell omics in dissecting immune microenvironment of malignant gliomas – challenges and perspectives” Cells 10(9), 2264 (2021). https://doi.org/10.3390/cells10092264
Pilanc P, Wojnicki K, Roura AJ, Cyranowski S, Ellert-Miklaszewska A, Ochocka N, Gielniewski B, Grzybowski MM, Błaszczyk R, Stańczak PS, Dobrzański P, Kaminska B. “A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment.” Front Oncol. 2021 Aug 24;11:703465. doi: 10.3389/fonc.2021.703465.
Ellert-Miklaszewska, A., Ochocka, N., Maleszewska, M., Ding, L., Laurini, E., Jiang, Y., Roura, A. J., Giorgio, S., Gielniewski, B., Pricl, S., Peng, L., & Kaminska, B. (2019). “Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector.” Nanomedicine, 14(18). https://doi.org/10.2217/nnm-2019-0176
Guneykaya, D., Ivanov, A., Hernandez, D. P., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., Ochocka, N., Cömert, C., Friedrich, C., Artiles, L. S., Kaminska, B., Mertins, P., Beule, D., Kettenmann, H., & Wolf, S. A. (2018). “Transcriptional and Translational Differences of Microglia from Male and Female Brains.” Cell Reports, 24(10), 2773–2783. https://doi.org/10.1016/j.celrep.2018.08.001
Walentynowicz, K. A., Ochocka, N., Pasierbinska, M., Wojnicki, K., Stepniak, K., Mieczkowski, J., Ciechomska, I. A., & Kaminska, B. (2018). “In search for reliable markers of glioma-induced polarization of microglia.” Frontiers in Immunology, 9(JUN), 1–13. https://doi.org/10.3389/fimmu.2018.01329

Research groups

We are interested in creating new approaches for comprehensive inference of developmental trajectories and delineation of cell atlases from single-cell data, understanding the role of cell-to-cell signaling and biological pathways in lineage commitment and transitions between cellular states.

Projects

15.12.2024

Development of new experimental approaches and computational tools for the analysis of single-cell sequencing data

Computational work in our lab focuses on developing new algorithms and scalable tools for analysis of massive single-cell datasets originated from wet lab and their integration across platforms and techniques. In particular, we are interested in creating new approaches for comprehensive inference of developmental trajectories and delineation of cell atlases from single-cell data, understanding the […]

Research groups

Computational Genomics Group

Projects

Development of new experimental approaches and computational tools for the analysis of single-cell sequencing data