Magdalena Banach-Orłowska, PhD

Dr. Magdalena Banach-Orłowska graduated from Biotechnology at the University of Warsaw. She obtained a PhD degree in Biochemistry at the Institute of Biochemistry and Biophysics (awarded with the Prime Minister award for a PhD thesis). She continued her scientific work as a postdoctoral fellow and senior researcher at the International Institute of Molecular and Cell Biology, and at the Medical University of Warsaw.

She led two scientific grants as a PI, co-promoted one PhD and published thirteen papers including twelve original (Scopus preview – Banach-Orłowska, Magdalena – Author details – Scopus). Her scientific interests focus mostly on intracellular signaling and regulation of gene expression in cancer cells.

Koppolu A, Maksym RB, Paskal W, Machnicki M, Rak B, Pępek M, Garbicz F, Pełka K, Kuśmierczyk Z, Jacko J, Rydzanicz M, Banach-Orłowska M, Stokłosa T, Płoski R, Malejczyk J, Włodarski PK., “Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes”, Cells, Mar 29;10(4):749, (2021)
Maksymowicz M, Miączyńska M, Banach-Orłowska M., “Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor”, Cell Commun Signal., Nov 4;18(1):176, (2020)
Banach-Orłowska M, Wyszyńska R, Pyrzyńska B, Maksymowicz M, Gołąb J, Miączyńska M, “Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling”, Cell Commun Signal. Dec 26;17(1):171, (2019 )
Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M., “The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome“, J Cell Sci., Nov 21;131(22):jcs218883, (2018)
Mamińska A, Bartosik A, Banach-Orłowska M, Pilecka I, Jastrzębski K, Zdżalik-Bielecka D, Castanon I, Poulain M, Neyen C, Wolińska-Nizioł L, Toruń A, Szymańska E, Kowalczyk A, Piwocka K, Simonsen A, Stenmark H, Fürthauer M, González-Gaitán M, Miaczynska M., “ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors”, Sci Signal., Jan 19;9(411):ra8, (2016)
Banach-Orlowska M, Szymanska E, Miaczynska M., “APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.”, FEBS Lett., Feb 13;589(4):532-9, (2015)
Pyrzynska B, Banach-Orlowska M, Teperek-Tkacz M, Miekus K, Drabik G, Majka M, Miaczynska M., “Multifunctional protein APPL2 contributes to survival of human glioma cells”, Mol Oncol.Feb;7(1):67-84, (2013)
Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M., „Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.”, Biochem J., Oct 12;423(3):389-400, (2009)
Makiela-Dzbenska K, Jaszczur M, Banach-Orlowska M, Jonczyk P, Schaaper RM, Fijalkowska IJ., “Role of Escherichia coli DNA polymerase I in chromosomal DNA replication fidelity.”, Mol Microbiol., Dec;74(5):1114-27, (2009)
Pilecka I, Banach-Orlowska M, Miaczynska M., “Nuclear functions of endocytic proteins.“, Eur J Cell Biol., Sep;86(9):533-47, (2007)
Kuban W, Banach-Orlowska M, Schaaper RM, Jonczyk P, Fijalkowska IJ., „Role of DNA polymerase IV in Escherichia coli SOS mutator activity.“, J Bacteriol., Nov;188(22):7977-80, (2006)
Banach-Orlowska M, Fijalkowska IJ, Schaaper RM, Jonczyk P., „DNA polymerase II as a fidelity factor in chromosomal DNA synthesis in Escherichia coli.”, Mol Microbiol., Oct;58(1):61-70, (2005)
Kuban W, Banach-Orlowska M, Bialoskorska M, Lipowska A, Schaaper RM, Jonczyk P, Fijalkowska IJ., „Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand.”, J Bacteriol., Oct;187(19):6862-6, (2005)

Research groups

We are interested in creating new approaches for comprehensive inference of developmental trajectories and delineation of cell atlases from single-cell data, understanding the role of cell-to-cell signaling and biological pathways in lineage commitment and transitions between cellular states.

Magdalena Banach-Orłowska, PhD

Research groups

Computational Genomics Group

Projects